Whitepaper
Methods for Determining Equipment Capability of Freeze-Dryers
Resource Overview
Lyophilization is a drug manufacturing process that involves freezing the formulation, drying the frozen ice under vacuum, and subsequent removal of unfrozen residual water. The pharmaceutical freeze-drying technique is constantly evolving to achieve improvements through a better understanding of the product and process conditions and the efficiency of the equipment. This white paper describes two experimental methods of determining “choked flow”, namely the minimum controllable pressure method and choke point method.
In this whitepaper learn more from the Simtra BioPharma Solutions team on methods for determining equipment capability of freeze-dryers.
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