Antibody drug conjugates (ADCs) have emerged as a leading option in cancer therapy due to their targeted specificity and minimal side effects and toxicity. Given the low bioavailability and the instability of the linker connecting the antibody and the chemotherapeutic agent, these drugs are typically developed in a lyophilized form. To assess the stability of lyophilized drug products, long-term stability studies are typically conducted at the intended storage temperature (usually ambient or refrigerated) over a period of at least two years. While accelerated stressed stability studies can be performed at higher temperatures, the storage temperature must not exceed the glass transition temperature (Tg) of the drug product, which can be relatively low depending on the formulation’s components and excipients. Therefore, there is a pressing need for new analytical methods to predict protein stability in a shorter timeframe. Hydrogen Deuterium Exchange (HDX) has been employed to investigate protein conformation and dynamics in solution with high resolution. <\/p>\n
In this whitepaper learn more from the Simtra BioPharma Solutions team in collaboration with Professor Elizabeth Topp\u2019s research group at Purdue University about the use of Solid State Hydrogen Deuterium Exchange to Study Antibody Drug Conjugate Stability<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":""},"class_list":["post-2267","resource","type-resource","status-publish","hentry"],"acf":[],"yoast_head":"\n