{"id":2251,"date":"2025-11-07T10:40:46","date_gmt":"2025-11-07T15:40:46","guid":{"rendered":"https:\/\/simtra.com\/?post_type=resource&#038;p=2251"},"modified":"2025-11-07T10:40:46","modified_gmt":"2025-11-07T15:40:46","slug":"stopper-migration-in-frozen-pre-filled-syringes","status":"publish","type":"resource","link":"https:\/\/simtra.com\/de\/resource\/stopper-migration-in-frozen-pre-filled-syringes\/","title":{"rendered":"Stopper Migration in Frozen Pre-Filled Syringes"},"content":{"rendered":"<p>Parenteral products provided as pre-filled syringes (PFS) offer unique benefits to both the patient and manufacturer. Because the closure system \u2013 i.e. plunger \u2013 is inherently mobile, environmental factors must be considered to ensure that the sterility of the product is maintained during storage, transport, and handling before administration. Chief among these factors are temperature and pressure fluctuations which occur during transport at elevation or in the holds of aircraft, especially for frozen products.<\/p>\n<p>This whitepaper from Simtra BioPharma Solutions presents a semi-automated method of dynamically assessing plunger migration during controlled variations of temperature and pressure using computer vision tools.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":""},"class_list":["post-2251","resource","type-resource","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Stopper Migration in Frozen Pre-Filled Syringes &#8212; Simtra BioPharma Solutions<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/simtra.com\/de\/resource\/stopper-migration-in-frozen-pre-filled-syringes\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stopper Migration in Frozen Pre-Filled Syringes &#8212; Simtra BioPharma Solutions\" \/>\n<meta property=\"og:description\" content=\"Parenteral products provided as pre-filled syringes (PFS) offer unique benefits to both the patient and manufacturer. Because the closure system \u2013 i.e. plunger \u2013 is inherently mobile, environmental factors must be considered to ensure that the sterility of the product is maintained during storage, transport, and handling before administration. Chief among these factors are temperature...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/simtra.com\/de\/resource\/stopper-migration-in-frozen-pre-filled-syringes\/\" \/>\n<meta property=\"og:site_name\" content=\"Simtra BioPharma Solutions\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/simtra.com\\\/de\\\/resource\\\/stopper-migration-in-frozen-pre-filled-syringes\\\/\",\"url\":\"https:\\\/\\\/simtra.com\\\/de\\\/resource\\\/stopper-migration-in-frozen-pre-filled-syringes\\\/\",\"name\":\"Stopper Migration in Frozen Pre-Filled Syringes &#8212; Simtra BioPharma Solutions\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/simtra.com\\\/de\\\/#website\"},\"datePublished\":\"2025-11-07T15:40:46+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/simtra.com\\\/de\\\/resource\\\/stopper-migration-in-frozen-pre-filled-syringes\\\/#breadcrumb\"},\"inLanguage\":\"de-DE\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/simtra.com\\\/de\\\/resource\\\/stopper-migration-in-frozen-pre-filled-syringes\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/simtra.com\\\/de\\\/resource\\\/stopper-migration-in-frozen-pre-filled-syringes\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/simtra.com\\\/de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Stopper Migration in Frozen Pre-Filled Syringes\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/simtra.com\\\/de\\\/#website\",\"url\":\"https:\\\/\\\/simtra.com\\\/de\\\/\",\"name\":\"Simtra BioPharma Solutions\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/simtra.com\\\/de\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/simtra.com\\\/de\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de-DE\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/simtra.com\\\/de\\\/#organization\",\"name\":\"Simtra BioPharma Solutions\",\"url\":\"https:\\\/\\\/simtra.com\\\/de\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de-DE\",\"@id\":\"https:\\\/\\\/simtra.com\\\/de\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/simtra.com\\\/wp-content\\\/uploads\\\/2024\\\/08\\\/Simtra_Lockup_RGB__All_Black.png\",\"contentUrl\":\"https:\\\/\\\/simtra.com\\\/wp-content\\\/uploads\\\/2024\\\/08\\\/Simtra_Lockup_RGB__All_Black.png\",\"width\":1000,\"height\":390,\"caption\":\"Simtra BioPharma Solutions\"},\"image\":{\"@id\":\"https:\\\/\\\/simtra.com\\\/de\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Stopper Migration in Frozen Pre-Filled Syringes &#8212; Simtra BioPharma Solutions","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/simtra.com\/de\/resource\/stopper-migration-in-frozen-pre-filled-syringes\/","og_locale":"de_DE","og_type":"article","og_title":"Stopper Migration in Frozen Pre-Filled Syringes &#8212; Simtra BioPharma Solutions","og_description":"Parenteral products provided as pre-filled syringes (PFS) offer unique benefits to both the patient and manufacturer. 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